From the LSD-sure crystal composition, the facet chain with the lid residue L209EL2 sorts in depth hydrophobic contacts with the two LSD and encompassing residues in TMs III, IV, and V (Figure 4C). If the lid moved aside to reveal the binding pocket in simulation, many of such contacts broke. https://fractal-storm-self-laid56420.blog2freedom.com/35091880/lsd-crystal-can-be-fun-for-anyone