The recognized effect of these PTMs on ATXN2’s purpose and SCA2 pathogenesis stays restricted. In other polyQ ailments, numerous research instructed that proteolytic cleavage of polyQ proteins could Participate in an important purpose in pathogenesis [36, 45]. Aligned with this thought, the presence of the enriched 42 kDa fragment in the https://q-vd-oph79123.aioblogs.com/81977589/l-162-things-to-know-before-you-buy