An interaction concerning histaminergic and opioidergic systems within the CNS was proposed almost 30 many years back, through an observation that morphine administration resulted in the discharge of histamine and its greater turnover inside the periaqueductal grey (Nishibori, Oishi, Itoh, & Saeki, 1985), suggesting that analgesia produced by opioids https://is-conolidine-safe33120.blogocial.com/block-pain-receptors-with-proleviate-no-further-a-mystery-62959616