Having said that, proof linking APOBEC3 enzymes to R-loop-connected mutation and genome instability is missing besides a report postulating that U/G mismatches, that may be made by C-to-U deamination of R-loop ssDNA followed by R-loop dissolution and DNA reannealing, may be to blame for a synthetic lethal interaction in between https://pressetexte87542.blogvivi.com/22518980/considerations-to-know-about-site-directed-mutagenesis